SCHEMA THERAPY VERSUS COGNITIVE BEHAVIORAL THERAPY VERSUS INDIVIDUAL SUPPORTIVE THERAPY FOR DEPRESSION IN AN INPATIENT AND DAY CLINIC SETTING: STUDY PROTOCOL OF THE OPTIMA-RCT

Abstract Background Major depressive disorder represents (MDD) a major cause of disability and disease burden.Beside antidepressant medication, psychotherapy is a key approach of treatment.Schema therapy has been shown to be effective in the treatment of psychiatric disorders, especially personality disorders, in a variety of settings and patient g

Clinical observation of a patient with an orphan disease (mucinous peritoneal carcinomatosis) after 2 courses of intraoperative photodynamic therapy with photogem photosensitizer is presented.During the first course of photodynamic therapy, photogem was administered at a dose of 2.5 mg/kg, the energy density of the Construction Toys laser radiation

Summary: The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor suppressor.Here, a degron is applied to detect rapid loss of chromatin accessibility at thousands of loci where ARID1A acts to generate accessible Mecate Reins minidomains of nucleosomes.Loss of ARID1A also results in the redistribution of the coactivator EP300.

Abstract Background Gliomas account for about 80% of all malignant brain and other central nervous system (CNS) tumors.Temozolomide (TMZ) resistance represents a major treatment hurdle.Adrenomedullin (ADM) has been reported to induce glioblastoma cell growth.Methods Cell viability was measured using the CCK-8 assay.The apoptosis analysis was perfor

This article examines the problems of the growth of juvenile delinquency.The causes and conditions of the increase in crime among persons under the age of majority are assessed.The paper analyzes the statistics of the growth of juvenile delinquency, the consequences, Universal Simmerstat measures of prevention and prevention of this type of crime.T